Diminishing return for mechanistic therapeutics with neurodegenerative disease duration?
نویسندگان
چکیده
منابع مشابه
Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease
Protein misfolding is implicated in numerous neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease. A unifying feature of patients with these disorders is the accumulation of deposits comprised of misfolded protein. Aberrant protein folding can cause toxicity through a loss or gain of protein function, or both. An...
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ژورنال
عنوان ژورنال: BioEssays
سال: 2016
ISSN: 0265-9247
DOI: 10.1002/bies.201600048